الجوهرة المصونة *****
المشاركات : 17164
العمـر : 36
تعاليق : مشرفة الطب والصحة
المزاج :
الدولة :
المهنة :
الهواية :
التسجيل : 10/10/2008
النقاط : 18248
التقييم : 501
توفيقك يارب
| موضوع: Williams syndrome الثلاثاء أغسطس 10, 2010 4:26 pm | |
| Williams syndrome (WS or WMS; also Williams–Beuren syndrome or WBS) is a rare neurodevelopmental disorder caused by a deletion of about 26 genes from the long arm of chromosome 7.[1] It is characterized by a distinctive, "elfin" facial appearance, along with a low nasal bridge; an unusually cheerful demeanor and ease with strangers; developmental delay coupled with unusual (for persons who are diagnosed as developmentally delayed) language skills; and cardiovascular problems, such as supravalvular aortic stenosis and transient hypercalcaemia. The syndrome was first identified in 1961 by Dr. J. C. P. Williams of New Zealand[2] and has an estimated prevalence of 1 in 7,500 to 1 in 20,000 births.[1]
Signs and symptoms
The most common symptoms of Williams syndrome are mental disability, heart defects, and unusual facial features. Other symptoms include failure to gain weight appropriately in infancy and low muscle tone. Most individuals with Williams syndrome are highly verbal and overly sociable, having what has been described as a "cocktail party" type personality, and exhibit a remarkable blend of cognitive strengths and weaknesses. Individuals with WS hyperfocus on the eyes of others in social engagements.[3] Patients tend to have widely spaced teeth, a long philtrum, and flattened nasal bridge.[4] Individuals with Williams syndrome also experience many cardiac problems, commonly heart murmurs and the narrowing of major blood vessels as well as supravalvular aortic stenosis. Other symptoms may include many gastrointestinal problems, such as abdominal pain and diverticulitis, as well as hormone problems, the most common being hypercalcemia (elevated calcium levels in the blood). Hypothyroidism has been reported to occur in children, although there is no proof of it occurring in adults; diabetes has been reported to occur in adults with WS as young as 21 years old.[5]
People with Williams syndrome often have hyperacusis and phonophobia which resembles noise-induced hearing loss, but this may be due to a malfunctioning auditory nerve.[6][7] However, individuals with WS can also tend to demonstrate a love of music[2], and appear significantly more likely to possess perfect pitch.[8] There also appears to be a higher prevalence of left-handedness and left-eye dominance.[9] Individuals with Williams syndrome also report higher anxiety levels as well as phobia development, which may be associated with hyperacusis.[10]
Furthermore, individuals with Williams syndrome have problems with visual processing, but this is related to difficulty in dealing with complex spatial relationships rather than to issues with depth perception.[11]
In an experiment, a group of children with Williams syndrome showed no signs of inherent racial bias, unlike children without the syndrome.[12]
While patients with Williams syndrome often have abnormal proficiency in verbal skills, they do not perform better on verbal tasks than average. This syndrome is characterized more by a deficiency in other areas of processing. Williams syndrome is notable in that respect in that it represents a double dissociation between verbal and spatial processing.
Nervous system
Because of the multiple genes that are missing in people with Williams syndrome, there are many effects on the brain, including abnormalities in the cerebellum, right parietal cortex, and left frontal cortical regions. This pattern is consistent with the visual-spatial disabilities and problems with behavioral timing often seen in Williams syndrome. Frontal-cerebellar pathways are involved in behavioral timing, and the parietal-dorsal areas of the neocortex handle visual processing that supports visual-spatial analysis of the environment (but not faces). People with Williams syndrome are often affable and hyperverbal – often blurting – which demonstrates the decreased inhibition ability that stems from dorsal-frontal deficits.[13] There have also been studies that show that the amygdala of a person with Williams syndrome has greater volume than the average person's, and given that the amygdala controls a human's sense of fear, it can be seen why WS individuals can so willingly talk to anyone, including strangers.[14]
Cause
Williams syndrome is caused by the deletion of genetic material from the region q11.23 of chromosome 7. The deleted region includes more than 25 genes, and researchers believe that the loss of several of these genes probably contributes to the characteristic features of this disorder. CLIP2, ELN, GTF2I, GTF2IRD1, and LIMK1 are among the genes that are typically deleted in people with Williams syndrome. Researchers have found that loss of the ELN gene, which codes for the protein elastin, is associated with the connective-tissue abnormalities and cardiovascular disease (specifically supravalvular aortic stenosis and supravalvular pulmonary stenosis) found in many people with this syndrome. Studies suggest that deletion of LIMK1, GTF2I, GTF2IRD1, and perhaps other genes may help explain the characteristic difficulties with visual–spatial tasks. Additionally, there is evidence that the loss of several of these genes, including CLIP2, may contribute to the unique behavioral characteristics, learning disabilities, and other cognitive difficulties seen in Williams syndrome
Treatment
There is no cure for Williams syndrome. Suggestions include avoiding taking extra calcium and vitamin D, and treating high levels of blood calcium, if present. Blood vessel narrowing can be a significant health problem as well, and is treated on an individual basis. Physical therapy is helpful to patients with joint stiffness. Developmental and speech therapy can also help these children (for example, verbal strengths can help make up for other weaknesses). Other treatments are based on a patient's particular symptoms.[4] Guidelines published by the American Academy of Pediatrics include cardiology evaluations, developmental and psychoeducational assessment, and many other examination, laboratory, and anticipatory guidance recommendations | |
|
نورس *********
المشاركات : 30951
العمـر : 93
تعاليق : مؤسس منتدى النورس
المزاج :
الدولة :
المهنة :
الهواية :
التسجيل : 09/10/2008
النقاط : 39243
التقييم : 1559
| موضوع: رد: Williams syndrome الخميس أغسطس 12, 2010 1:46 pm | |
| باركـ الله فيكِ جوهرة القصر
دمتِ بود
| |
|
عاشقة الزهور *****
المشاركات : 75737
العمـر : 40
المزاج :
الدولة :
المهنة :
الهواية :
التسجيل : 09/03/2009
النقاط : 101796
التقييم : 846
| موضوع: رد: Williams syndrome الجمعة أغسطس 13, 2010 8:10 am | |
| | |
|
الجوهرة المصونة *****
المشاركات : 17164
العمـر : 36
تعاليق : مشرفة الطب والصحة
المزاج :
الدولة :
المهنة :
الهواية :
التسجيل : 10/10/2008
النقاط : 18248
التقييم : 501
توفيقك يارب
| موضوع: رد: Williams syndrome الثلاثاء أغسطس 24, 2010 10:25 am | |
| | |
|